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Cornea

Congenital hereditary endothelial dystrophy

CHED

1:477 visual cues1 clinical photo

In this image

Each number marks an object in the image and the finding it stands for.

  1. Boss babyPresents at birth
  2. Reese's throneAutosomal recessive inheritance
  3. Cheese factory signSLC4A11 mutation
  4. Flooded factoryBilateral diffuse corneal haze; Edema, limbus to limbus
  5. Nearly empty beltEndothelial cells absent; Or severely reduced
  6. Thick pink layerThickened Descemet membrane; PAS positive
  7. Slice under layerEndothelial keratoplasty; DMEK / DSEK
  8. ReviewEvery marker, in order

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Clinical image credits

Openly licensed photographs used in this lesson, with what was changed.

  1. Salman, Mohd, Verma, Anshuman, Chaurasia, Sunita, Prasad, Deeksha, Kannabiran, Chitra, Singh, Vivek, Ramappa, Muralidhar (2022). Identification and in silico analysis of a spectrum of SLC4A11 variations in Indian familial and sporadic cases of congenital hereditary endothelial dystrophy.

    CC BY 4.0Article

    Exact rectangular crop [0, 234, 424, 417] from 1959 × 1893 publisher figure. Decoded RGB pixels preserved; no enhancement, arrows, retouching or upscaling.