Skip to content
AfterImage
Menu

Retina and optic nerve

Leber hereditary optic neuropathy

LHON

3:2812 visual cues3 clinical photos

In this image

Each number marks an object in the image and the finding it stands for.

  1. Young lionYoung adults; strong male predominance
  2. MotherMaternal mitochondrial inheritance
  3. BatteryComplex I dysfunction
  4. Badges11778 / ND4; 3460 / ND1; 14484 / ND6
  5. 1177811778 (ND4): most common
  6. 1448414484 (ND6): best prognosis
  7. Power stationMitochondrial energy-production failure
  8. DonutCentral / cecocentral scotoma
  9. HeadlightsSubacute, painless, sequential bilateral loss
  10. Red wiresAcute peripapillary telangiectatic microangiopathy
  11. Cable bundleAcute peripapillary RNFL swelling
  12. Pale hubChronic optic atrophy
  13. ReviewEvery marker, in order

Transcript

The narration, grouped by cue. Select a sentence to play from there.

Suggest an addition

Know a high-yield fact that deserves an anchor in this image, or spotted a mistake? Only the AfterImage team sees what you send.

Clinical image credits

Openly licensed photographs used in this lesson, with what was changed.

  1. Tereza Rákosníková, Silvie Kelifová, Hana Štufková, Kateřina Lokvencová, Petra Lišková, Bohdan Kousal, Tomáš Honzík, Hana Hansíková, Václav Martínek, Markéta Tesařová (2023). Case report: A rare variant m.4135T>C in the MT-ND1 gene leads to Leber hereditary optic neuropathy and altered respiratory chain supercomplexes. Figure 1G.

    CC BY 4.0ArticleDOI

    Exact rectangular crop [540, 1083, 817, 1364] from 1772 × 1907 publisher original, preserving decoded RGB pixels. No other changes, arrows, retouching, enhancement or upscaling.

  2. Azmi, Silim, Sawri Rajan, Nasaruddin (2025). Recurrent Optic Neuritis as a Misleading Presentation of Leber Hereditary Optic Neuropathy: The Need for High Clinical Suspicion in Young Men. Figure 1.

    CC BY 4.0ArticleDOI

    Exact rectangular crop [0, 0, 750, 329] from the 750 × 329 publisher original (Figure 1), preserving decoded RGB pixels. The authors' own arrows and markings are kept; no other changes, retouching, enhancement or upscaling.

  3. Tereza Rákosníková, Silvie Kelifová, Hana Štufková, Kateřina Lokvencová, Petra Lišková, Bohdan Kousal, Tomáš Honzík, Hana Hansíková, Václav Martínek, Markéta Tesařová (2023). Case report: A rare variant m.4135T>C in the MT-ND1 gene leads to Leber hereditary optic neuropathy and altered respiratory chain supercomplexes. Figure 1A.

    CC BY 4.0ArticleDOI

    Exact rectangular crop [0, 0, 817, 817] from 1772 × 1907 publisher original, preserving decoded RGB pixels. No other changes, arrows, retouching, enhancement or upscaling.