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Cornea

Reis-Bücklers corneal dystrophy

2:209 visual cues3 clinical photos

In this image

Each number marks an object in the image and the finding it stands for.

  1. Belt buckleReis-Bücklers corneal dystrophy
  2. DominoAutosomal dominant inheritance
  3. Gene and badgeTGFBI; R124L mutation
  4. SheetBowman’s layer replaced; Sheet-like connective tissue
  5. Buckle patternGeographic corneal opacification
  6. Red mason jarGranular hyaline in Bowman’s layer; Red with Masson trichrome
  7. Held batonRod-like bodies on electron microscopy
  8. Table holesRecurrent corneal erosions
  9. Transplant photosVery high transplant rejection rate
  10. ReviewEvery marker, in order

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Clinical image credits

Openly licensed photographs used in this lesson, with what was changed.

  1. Wen-Ya Qiu, Li-Bin Zheng, Fei Pan, Bei-Bei Wang, Yu-Feng Yao (2016). New histopathologic and ultrastructural findings in Reis-Bücklers corneal dystrophy caused by the Arg124Leu mutation of TGFBI gene.

    CC BY 4.0Article

    Exact rectangular crop [593, 1, 1182, 443] from 1183 × 876 publisher figure. Decoded RGB pixels preserved; no enhancement, arrows, retouching or upscaling.

  2. Wen-Ya Qiu, Li-Bin Zheng, Fei Pan, Bei-Bei Wang, Yu-Feng Yao (2016). New histopathologic and ultrastructural findings in Reis-Bücklers corneal dystrophy caused by the Arg124Leu mutation of TGFBI gene.

    CC BY 4.0Article

    Exact rectangular crop [2, 477, 589, 946] from 1183 × 1421 publisher figure. Decoded RGB pixels preserved; no enhancement, arrows, retouching or upscaling.

  3. Wen-Ya Qiu, Li-Bin Zheng, Fei Pan, Bei-Bei Wang, Yu-Feng Yao (2016). New histopathologic and ultrastructural findings in Reis-Bücklers corneal dystrophy caused by the Arg124Leu mutation of TGFBI gene.

    CC BY 4.0Article

    Exact rectangular crop [949, 708, 1419, 1179] from 1420 × 1180 publisher figure. Decoded RGB pixels preserved; no enhancement, arrows, retouching or upscaling.